Edward and Alphonse Elric arrive in the desert city of Lior, a town gripped by the zealotry of Father Cornello. The brothers quickly realize Cornello is using a fake Philosopher's Stone to perform "miracles" and manipulate the desperate citizens.
The dark reality of the Elric brothers' past is exposed when Cornello attempts to kill them. Ed reveals his automail limbs and Al's hollow armor body, proving the horrific price they paid for violating alchemy's ultimate taboo.
A devastating flashback details the brothers' childhood following their mother's death. Desperate to bring her back, they study alchemy under Izumi Curtis, culminating in the disastrous human transmutation that cost them their bodies.
On their way to Central City, the brothers cross paths with Majhal, an alchemist obsessed with creating life to replace his lost love. The episode serves as a grim warning of how obsession can deeply corrupt an alchemist's soul.
A train hijacking forces the Elrics into action, putting them on the radar of Colonel Roy Mustang. The incident highlights the simmering political tensions within Amestris and introduces the military's ruthless efficiency.
Edward takes the grueling State Alchemist exam. He moves in with Shou Tucker, the "Sewing-Life Alchemist," and bonds with his daughter Nina, unaware of the immense pressure Tucker is under to produce results.
Faced with losing his military funding, Shou Tucker commits an unthinkable atrocity by fusing his daughter Nina and her dog into a chimera. The Elric brothers are left completely shattered by their inability to save her.
The serial killer Barry the Chopper kidnaps Winry, forcing Ed into a terrifying confrontation. Ed realizes how close he is to losing his own humanity, traumatized by the violence required to survive as a dog of the military.
Ed is officially given his silver pocket watch and the title of "Fullmetal Alchemist." He is immediately sent to inspect the corrupt mining town of Youswell, where he uses his sharp wit to outsmart a tyrannical military lieutenant.
The brothers visit the beautiful water city of Aquroya, which is scheduled to be demolished. They get tangled up with a brilliant, acrobatic phantom thief named Psiren who uses alchemy to steal from the corrupt.
Ed and Al arrive in a town where two imposters are parading around using their names. The situation becomes complicated when they discover the imposters are researching a terrifying substance known as Red Water.
The true nature of the Red Water is revealed as a toxic precursor to the Philosopher's Stone. The Elrics must save the imposters from a corrupt local lord and stop the town from being poisoned by the alchemical runoff.
In a highly anticipated, action-packed showdown, Edward challenges Roy Mustang to a duel during the annual military assessment. If Ed wins, Mustang must reveal his classified knowledge regarding the Philosopher's Stone.
The brothers encounter Scar, an Ishvalan survivor with a mysterious alchemical tattoo who is hunting down State Alchemists. Overmatched and terrified, Ed and Al narrowly escape the brutal encounter with their lives and armor in pieces.
While recovering from Scar's attack, Marcoh reveals the horrifying truth about the Ishvalan War of Extermination. The military used State Alchemists as human weapons to systematically slaughter the Ishvalan people using incomplete Philosopher's Stones.
Ed and Al travel to Resembool for repairs. The journey is delayed when Ed loses his automail leg, forcing him to rely entirely on Al while reflecting on the heavy physical and emotional toll their quest is taking.
Returning to their hometown of Resembool, Winry and Pinako Rockbell work exhaustively to rebuild Ed's shattered automail. The brothers find quiet comfort in the only place they can truly call home before heading back into the fray.
Back in Central City, Ed and Al gain access to the First Branch Library. They must decipher Dr. Marcoh's heavily encrypted research notes, only to uncover an ingredient for the Philosopher's Stone that makes their blood run cold: living humans.
Following the clues in Marcoh's notes, the brothers break into the abandoned, highly classified Military Laboratory 5. They immediately trigger the facility's defenses, separating them into two terrifying, isolated battles for survival.
Alphonse is confronted by Barry the Chopper, whose soul has been bound to a suit of armor just like his. Barry exploits Al's deepest insecurities, planting the horrific idea that Al's memories might be entirely fabricated by Edward.
Deep inside Laboratory 5, Ed discovers the massive transmutation circle designed to sacrifice prisoners. He is confronted by the Homunculi Lust and Envy, who attempt to force him into completing the dark ritual.
The laboratory begins to collapse. Ed is severely injured and rescued by the military, while Alphonse is left grappling with an existential crisis about whether his soul and memories are real or just alchemical programming.
Tensions boil over as Al accuses Ed of fabricating his existence. A violent, deeply emotional fight breaks out between the brothers, forcing them to confront the unspoken trauma they have carried since their failed transmutation.
The brothers finally reconcile, reaffirming their unshakeable bond. Meanwhile, Maes Hughes uncovers a massive, terrifying conspiracy hidden within the military's top brass, making him a prime target for the Homunculi.
In one of the most heartbreaking moments of the series, Hughes is murdered by Envy disguised as his wife. The military mourns the loss of a great man, while Mustang silently vows to hunt down those responsible.
Ed and Al are finally reunited with their terrifying alchemy teacher, Izumi Curtis. Izumi quickly deduces the horrifying truth that the boys attempted human transmutation, violently expelling them from her tutelage before demanding to know exactly what they saw inside the Gate.
Izumi strands the brothers on a deserted island for a month to test their resolve, mirroring the brutal survival training they endured as children. Through starvation and isolation, Ed and Al rediscover the fundamental alchemical philosophy that the universe is a massive, interconnected flow of energy.
A mysterious, feral boy with the ability to use alchemy without a circle is discovered on Izumi's island. The boy, possessing Ed's missing right arm and left leg, is revealed to be Wrath—the horrific result of Izumi's own failed attempt to resurrect her stillborn infant.
The rogue Homunculus known as Greed makes his move, recognizing the immense value of Alphonse's blood-sealed armor. Greed launches a coordinated, brutal assault on the military's Southern Headquarters using his team of heavily modified chimera outcasts.
Ed tracks Alphonse to the Devil's Nest, an underground bar operating as Greed's sanctuary. Inside, Greed explains the true nature of the Homunculi in this timeline: they are the tortured, soulless byproducts of alchemists who dared to play God by attempting human transmutation.
Ed seeks guidance from Dante, Izumi's former alchemy teacher, a mysterious elderly woman living deep in the woods. Dante's vast knowledge of alchemy hides a dark, sprawling history connected to Hohenheim and the true origins of the Philosopher's Stone.
The military, led by a ruthless King Bradley, violently raids the Devil's Nest, slaughtering Greed's chimera friends without mercy. In the chaos, Greed takes Alphonse captive, realizing that the secret to immortality might lie in how Al's soul is bound to inorganic matter.
Ed engages Greed in a savage, bloody duel. Realizing that Greed's "Ultimate Shield" relies on rearranging the carbon in his body, Ed uses alchemy to alter Greed's molecular structure, delivering a fatal blow that leaves Ed horrified by his own capacity for murder.
The brothers return to Lior, only to find the city torn apart by civil war instigated by the Homunculi. Lust begins to question her own existence and the fragmented memories of her past life, slowly realizing she is being used as a pawn by a higher power.
A deeply unsettling flashback delves into the military's massacre in Ishval. The episode exposes the psychological destruction of the State Alchemists forced to act as living weapons, and reveals how Scar's brother sacrificed himself to give Scar his destructive tattooed arm.
A brilliantly timed, comedic breather episode focusing on Roy Mustang's subordinates as they investigate a supposed haunting in a military warehouse. It offers a rare glimpse of levity and camaraderie before the narrative plunges into absolute darkness.
Winry and Sheska team up to investigate the conspiracy surrounding Maes Hughes' death, stumbling into a deadly confrontation with Sloth. Winry is forced to confront the terrifying reality of the military's shadow government and the danger Ed and Al are truly in.
Scar's tragic backstory is fully unveiled, detailing his desperate attempt to save his people using the forbidden alchemy his brother researched. The military prepares to annihilate Lior, trapping the Elric brothers in a city about to be wiped off the map.
Scar enacts a massive, city-wide transmutation circle in Lior, intending to sacrifice the invading military forces to create a Philosopher's Stone. Ed frantically tries to stop him, but the overwhelming scale of the conflict spirals completely out of control.
The horrifying truth is finally revealed: the Homunculus Sloth is the physical manifestation of Trisha Elric, born from Ed and Al's failed human transmutation. The brothers are paralyzed by the trauma of facing the twisted, water-based abomination that wears their mother's face.
Hohenheim of Light, the Elrics' estranged father, unexpectedly returns. His confrontation with the Homunculi reveals his ancient, immortal past, his deep connection to Dante, and his overwhelming guilt for abandoning his sons to a cursed fate.
Realizing that the military high command is entirely controlled by the Homunculi, Roy Mustang orchestrates a brilliant, high-stakes coup d'état in Central City. He risks everything to expose the corruption and avenge the death of Maes Hughes.
Hohenheim confronts Dante in the underground city beneath Central. Their confrontation exposes the tragic, parasitic cycle they have perpetuated for centuries by jumping between host bodies using the Philosopher's Stone, a cycle Hohenheim refuses to continue.
Dante uses her mastery of alchemy to violently expel Hohenheim through the Gate of Truth. Meanwhile, Ed and Al desperately fight against Sloth, realizing they must destroy the creature that looks like their mother if they want to survive.
In a truly heartbreaking battle, Edward uses the remains of his mother to paralyze Sloth, allowing Wrath to unknowingly absorb her. The brothers are forced to accept that the dead cannot be brought back, no matter the alchemical cost.
Ed races into the underground city to rescue Alphonse, who has become the Philosopher's Stone itself. He faces off against Envy, who reveals his true form and his bitter, twisted connection to Hohenheim as the first Homunculus ever created.
Mustang stages his final, bloody assault against King Bradley (Pride). In the underground city, Envy delivers a fatal blow to Edward, piercing his heart. Alphonse, watching his brother die, makes a desperate, unthinkable decision.
Edward awakens in a completely different world—our reality, in early 20th-century London—discovering that the energy fueling alchemy actually comes from the deaths occurring in this parallel, non-magical universe. He realizes the horrifying cost of the power they wielded.
Alphonse uses the entirety of the Philosopher's Stone within his body to perform the ultimate human transmutation, sacrificing himself to resurrect Edward. Ed awakens with his limbs restored, but shatters at the realization of what Al has done.
Refusing to accept a world without his brother, Edward sacrifices his own body and soul to bring Alphonse back. Al awakens in Amestris in his original body with his memories erased, while Ed is left stranded in the parallel world of 1921 Munich, vowing to one day find a way home.